Sarcopenia is an age-related progressive loss of skeletal muscle mass, strength, and function. It significantly impairs mobility, increases the risk of falls, fractures, and disabilities, and reduces the quality of life. So far, there is no FDA approved pharmacological therapy for sarcopenia. Currently, pre-clinical animal models can be divided into four types: (1) aged animals; (2) genetically modified animals; (3) intervention models; (4) induced disuse models.

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